The protein Sonic Hedgehog (Hush), named in honor of the hedgehog star of the video game series by the Japanese company Sony, could alleviate the serious side effects of the most effective treatment for Parkinson’s disease, the University of the city of New York.
Currently, the therapy considered to be the most effective is to take the precursor of dopamine Levodopa (L-dopa). However, the prolonged use of this drug leads to involuntary movements of the muscles of the limbs, face and torso of the patients, which can only be relieved by the brain stimulation procedure which, in turn, also has various limitations.
This side effect, called L-dopa-induced dyskinesia (LID), however, is relieved by taking drugs that increase Shh signaling, scientists found. in rodents and primates. The researchers also determined a relationship between decreased protein levels and the development of symptoms of LID.
The treatment has yet to be tested in humans, but scientists are optimistic about its future.
“The deep brain stimulation doesn’t help at allIt is very invasive and not everyone is eligible for surgery. The procedure is not accessible to everyone either. What we found in this study is that, in various animal models, […] these dyskinesias can be largely suppressed», Explains one of the study’s authors, Andreas Kottman.
“We bring new information on the mechanisms underlying the formation of LID and a possible therapeutic solution”, underlines, in the same tone, his colleague Lauren Malave.
The study was published in the journal Nature Communications Biology.
Disclaimer: This article is generated from the feed and is not edited by our team.